Asghar Sadeghabadi; Nahid Hassanzadeh Nemati; Mohammad Reza Vaezi; Mohammad Taghi Khorasani
Abstract
Background: Total Hip prosthesis replacement is one of successful invasive procedures in medical history. Hip joint replacement started by Sir John charnley by using of low friction artificial joint on 1960s. Subsequently bearing material, fixation methods and new designs were defined and modified. The ...
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Background: Total Hip prosthesis replacement is one of successful invasive procedures in medical history. Hip joint replacement started by Sir John charnley by using of low friction artificial joint on 1960s. Subsequently bearing material, fixation methods and new designs were defined and modified. The main concerns about THA are biological response due to particles produced by bearing surfaces that lead to Osteolysis and prosthesis loosening. Modern THA biomaterials were developed to remedy this problem.Methods: A journal research strategy was performed using different terms. The highest quality technical articles and reports were selected that included the best and newest related contents. Key search words were hip, biomaterial, wear, titanium, zirconia, alumina, UHMWPE and CO-Cr. Finally 69 sources were chosen and used in this review.Results: Recent advances in hip prostheses have focused on mechanical strength, biocompatibility, bioactivity, increasing wear resistance and reliability using new technologies, as well as structure modification and nanotechnology hybridization. A hybrid design in nano-ceramics has increased resistance up to four times that of alumina, allowing for a smaller femoral head. The prosthesis stability, longer life, and reliability are needed due to the increase in young patients who need hip arthroplasty with higher activity levels, which can be achieved with scientific methods and newly improved materials.Conclusion: This study introduces the biomaterials used in hip joint prostheses and discussed them from different aspects. In addition, more advanced biomaterials for THA have also been investigated to further reduce wear and increase the life of the prosthesis in the future.
Banafsheh Jafargholizadeh; Nahid Hassanzadeh Nemati
Abstract
Introduction: An increasing population of the elderly has led to increasing demand for orthopedic implants. Excellent biocompatibility of orthodontic wires, drug delivery systems, cardiovascular stents, and orthopedic implants has attracted widespread attention by researchers for use in medical industries. ...
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Introduction: An increasing population of the elderly has led to increasing demand for orthopedic implants. Excellent biocompatibility of orthodontic wires, drug delivery systems, cardiovascular stents, and orthopedic implants has attracted widespread attention by researchers for use in medical industries. In some cases, however, superficial properties such as corrosion resistance and other biological behavior are not sufficient for clinical application. Infection caused by the presence of implants in the body is one of the most common complaints of patients. Since the bacteria play important role in patients ’disability, the development of antibacterial properties has been considered.Methods: Nanotubes, created on the surface of nitinol through anodizing, can be one of the useful solutions in creating antibacterial properties. Also, the ability of these structures to carry drugs such as antibiotics can solve the problems caused by implantation of orthopedic implants in the body.Results: In order to increase the long-term antibacterial ability of orthopedic implants, the researchers have improved the physical properties by modification of nitinol levels by anodizing method and the formation of nanotubes on its surface and drug loading.Conclusion: The effect of different parameters on morphology, nickel ion release, corrosion behavior, biological and drug delivery, applicable in orthopedic implants, is discussed.
Nahid Hassanzadeh Nemati; setareh nikzamir; zohreh ansarinezhad
Abstract
Background: Preserving the biological structure of the initial nature of cancellous bone could prepare it for a proper scaffold for successful bone tissue engineering. Moreover, it is vital to eliminate the cells belonging to its bed to increase its biocompatibility and reduce their immunological responses. ...
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Background: Preserving the biological structure of the initial nature of cancellous bone could prepare it for a proper scaffold for successful bone tissue engineering. Moreover, it is vital to eliminate the cells belonging to its bed to increase its biocompatibility and reduce their immunological responses. Methods: In this study, Chemical methods were used for decellularization of three-dimensional scaffolds made from spongy calfchr('39')s pelvic bone. For this purpose, the bone samples which were cut from calf pelvis bone were degreased, and then their cells were removed through chemical (sodium dodecyl sulfate (SDS) and TritonX-100 with different concentrations) method. The samples were characterized by hematoxylin and eosin staining, trichrome staining, and optical and scanning electron microscope. In the end, to ensure the absence of toxic substances in the scaffold, a cell toxicity test was conducted. Results: The results show that the decellularized samples with TritonX-100 of 2% and combining solution of 3% TritonX-100 and 4% SDS respectively (T3S4) can substitute for damaged cancellous bone tissue. The results indicated that calf pelvic spongy bone tissue, as a xenograft that has undergone decellularization with SDS and Triton x-100 chemical solutions, can produce an appropriate scaffold for bone tissue engineering. The natural bone tissue with preservation of collagen fibers and the presence of porosity in its structure can provide a suitable environment for tissue regeneration.. Conclusion: The results suggested that T3S4-acellular bone tissue can be further evaluated as a natural scaffold suitable for using in bone tissue engineering and restorative medicine.
